Quickzyme Biosciences is a Dutch bioscience company based in Leiden developing assays and services in the field of matrix proteins and proteases.

Cosmo Bio USA Co. is a leading distributor of antibodies, research kits, biological reagents, instruments and the Artemis TR-FRET microplate reader.

The ability to invade host tissues and metastasize is the major cause of cancer-related death. During tumor invasion, metastasizing cells disrupt normal cell-cell and cell-matrix contacts and acquire a migratory, invasive phenotype. Subsequent alterations in cellular architecture mediated by modified extracellular matrix (ECM) attachments induce expression of proteinases that degrade ECM proteins, facilitating migration through the modified tissue to establish metastatic foci. Although malignant cells produce a spectrum of matrix-degrading enzymes, predominant among these proteinases are enzymes in the plasminogen activator (PA) and matrix metalloproteinase (MMP) families. Current research centers on two model systems: ovarian carcinoma and squamous cell carcinoma of the oral cavity (OSCC).

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