SignalChem offers a diverse range of cellular signaling products including: Active Kinases, Active Phosphatases, Unactive Enzymes, Assay Kits, Protein Substrates and Peptide Substrates. SignalChem also offers a comprehensive discovery service which includes: gene cloning & expression of therapeutic 'targets', custom assay & antibody development and compound profiling for drug 'potency' & 'selectivity'. SignalChem’s compound selectivity profiling service determines the respective inhibitory profile and the putative mechanism of action. All compounds are profiled against a panel of targets either using an individual dose, a single concentration or at multiple concentrations in order to allow in-depth IC50 determinations. In addition, the protein kinase assays can be performed under varying ATP concentrations to evaluate the competitive effects of ATP. SignalChem scientist's have gained extensive experience in the cloning, expression, purification and activation of cellular signaling proteins including protein kinases, protein phosphatases and cellular protein substrates, amongst others.

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