Our research program focus on understanding macromolecular structures. We are interested in characterizing their shapes, and use this information to improve our understanding of their stability. We are also interested in characterizing the subset of sequence space compatible with a protein or nucleic acid structure: this is an indirect approach to understanding sequence evolution, both at the RNA and protein level. In parallel, we are involved in the development of new algorithms for predicting the structure of a protein, based on its sequence.

Bulgarian Supercomputing Centre Български суперкомпютърен център

The research of the NMR group aims at gaining fundamental insight into biological processes using solution and solid-state NMR spectroscopy as the main biophysical experimental techniques in combination with molecular biology and computational structural biology methods. Novel research concepts are being developed and applied to complex biomolecular systems including protein-protein and protein-nucleic acid complexes or membrane proteins.